Endocrine Abstracts

Objective: To evaluate the chance of developing new cases of Type 2 diabetes mellitus (DM) in obese people in the population sample of the city of Novosibirsk aged 45–69 years.Materials and methods: The analysis included 2464 people, including 586 (23.7%) men and 1878 (76.2%) women without DM. This sample was formed from the base of the international project HAPIEE surveyed from 2003 to 2005. When conducting a re-screening of the same sample in 2006...

We previously have reported that short-term treatment of mice with recombinant hGH leads to significant increases in bodyweight (BW), lean body mass (LBM) and liver weight, but – unlike in humans – does not robustly increase circulating levels of IGF1. We now tested the hypothesis that formation of neutralizing antibodies in mice treated with rhGH could explain the lack of IGF1 response. Therefore, we intentionally induced antibody formation against hGH in female FVB...